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Salomon Quest 4D 3 GTX Review | BBR 2778 was more cytotoxic in leukemia and lymphoma cell lines than in solid tumor cell lines. Although against in vivo models BBR 2778 was less potent than mitoxantrone and doxorubicin, its antitumor activity was equal or superior (in certain tumor models) to that of the above standard compounds. BBR 2778 is a novel aza-anthracenedione that has activity in experimental tumors and shows reduced potential for cardiotoxicity in animal models. This cytotoxic agent has structural similarities with mitoxantrone as well as general similarities with anthracyclines (such as the tricyclic central quinoid chromophore). Phase-II study of the new aza-anthracenedione, BBR 2778, in patients with relapsed aggressive non-Hodgkin's lymphomas These results indicate that 85 mg/m2 BBR 2778 in a q1w x 3 schedule is active in elderly and pretreated patients with relapsed aggressive NHL and was generally well tolerated. A novel aza-anthracenedione, pixantrone (BBR 2778), was developed to reduce treatment-related cardiotoxicity while retaining efficacy. This study evaluates the cumulative cardiotoxic potential of pixantrone compared with equiactive doses of doxorubicin and mitoxantrone in both doxorubicin-pretreated and doxorubicin-naïve mice.

av M Virefjäll · Citerat av 1 — naden når upp till BBR:s grundläggande krav för nybyggnad.13 som precis klarar de lägsta kraven enligt BBR. 0,100/0,036 = 2,778. Boverkets byggregler (BBR) · Brandsakkunnig · Brandskyddsbeskrivning/brandskyddsdokumentation · Brandsäkerhetskonsult/brandingenjör · Bruttoarea 2778,4. NKS totalt per invånare. 130 480 kr 122 315 kr 103 236 kr lägenheterna ska utrustas i enlighet med BBR´s klass 5B vilket är mer än 2778. 8005. 586.

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10. VÄVAREN *3. 2562 Boverkets byggregler (föreskrifter och allmänna råd), BBR 19. 27. av A OSHALIM · 2013 — Prefab. Långt.

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[4]. Ubiali F, et al. Pixantrone (BBR2778) reduces the severity of experimental autoimmune myasthenia gravis in Lewis rats. With the aim to provide second-generation anthracenedione analogues endowed with reduced side effects and a wider spectrum of action than mitoxantrone and doxorubicin, a … 2000-12-01 Boverkets byggregler – föreskrifter och allmänna råd, BBR Konsoliderad version (fulltext) 4 (152) Konsoliderad version (fulltext) 1:21 Mindre avvikelser från föreskrifterna i denna författning Byggnadsnämnden får i enskilda fall medge mindre avvikelser från föreskrifterna i denna författning.

DEH was synthesized by David E. Horn, Goucher College. Purity of all the compounds was assured using NMR and TLC. The photoaffinity probe NHS-ASA was purchased from Pierce.
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2. Novuspharma, an Italian company, was established in 1998 following the merger of Boehringer Mannheim and Hoffmann-La Roche, and BBR 2778 was developed as Novuspharma's leading anti-cancer drug, pixantrone. click for Download Citation | On Jan 1, 2000, E.B. Skibo published BBR-2778 Novuspharma SpA | Find, read and cite all the research you need on ResearchGate Pixantrone (BBR 2778) is an experimental antineoplastic drug.;Target: Pixantrone is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue, It acts as a topoisomerase II poison and intercalating agent. Pixantrone may be useful in patients pretreated with anthracyclines [1].

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infusions over a 4-week cycle (cy Original article Phase I study of BBR 2778, a new aza-anthracenedione, in advanced or refractory non-Hodgkinâ€™s lymphoma P. Borchmann, 1 R. Schnell, 1 R. Knippertz, 1 J.O. Staak, 1 G.M. Camboni, 2 A. Bernareggi, 2 K. HÃ¼bel, 1 P. Staib, 1 A. Schulz, 1 V. Diehl, 1 A. Engert, 1 [email protected] de 1 Klinik I fÃ¼r Innere Medizin der UniversitÃ¤t KÃ¶ln, KÃ¶ln, Germany Klinik I Cavalletti E, et al. Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone.